منابع مشابه
Assessment of aging effects on porcelain repair systems discoloration
Introduction: The selection of porcelain is based on high biocompatibility, endurance, superficial texture and aesthetics. Nevertheless, the innate fracture charateritics of porcelain is the main cause of the intra oral fractures. Electing a suitable porcelain restorative system in terms of stability of color is important. For this reason, this study aimed to examine the color changes of common...
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T cells play a critical role in acute allograft rejection. TGF-β/Smad3 signaling is a key pathway in regulating T cell development. We report here that Smad3 is a key transcriptional factor of TGF-β signaling that differentially regulates T cell immune responses in a mouse model of cardiac allograft rejection in which donor hearts from BALB/c mice were transplanted into Smad3 knockout (KO) and ...
متن کاملSmad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling.
Although Smad3 is a key mediator of fibrosis, the functional role of Smad3 in hypertensive cardiovascular disease remains unclear. The present study tested the hypothesis that angiotensin II may activate the transforming growth factor-beta/Smad3 pathway to mediate hypertensive cardiac remodeling in Smad3 knockout (KO) and wild-type mice by subcutaneous angiotensin II infusion and in the primary...
متن کاملInflammation in Muscle Repair, Aging, and Myopathies
1 DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy 2 Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Institució Catalana de Recerca i Estudis Avançats (ICREA), Doctor Aiguader 88, 08003 Barcelona, Spain 3The Biomedical Research...
متن کاملDNA Repair, Genome Stability, and Aging
Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability...
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ژورنال
عنوان ژورنال: Aging
سال: 2018
ISSN: 1945-4589
DOI: 10.18632/aging.101567